{"product_id":"ker-nano-e-450ml","title":"Ker Nano E 450ml","description":"\u003cp\u003eVitamin E is first and foremost an antioxidant, an agent that keeps free radicals from forming and potentially weakening cells and tissues. In addition to its antioxidant responsibilities, vitamin E is vital to immune, cardiovascular, circulatory, neuromuscular, and reproductive functions.\u003c\/p\u003e\n\u003cp\u003eThe availability and necessity of vitamin E in equine diets is well established. When healthy horses are given frequent access to fresh green forage such as good-quality pasture, there is little need for supplementation of vitamin E. However, many horses today are managed without fresh forage in their diets. These horses can survive in such management systems, but they will likely not be consuming sufficient vitamin E for optimal health.\u003c\/p\u003e\n\u003cp\u003eNano-E® uses advanced nanotechnology to create a rapidly available and absorbed source of vitamin E that enables administration to be timed to provide peak antioxidant protection to performance horses.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003eNano-E is a powerful water-soluble liquid vitamin E antioxidant supplement for horses in a unique, rapidly bioavailable form.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003eWhy should I use Nano-E for my horse?\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eVitamin E antioxidant supplement for all types of horses\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eNatural-source vitamin E proven more effective than synthetic vitamin E\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eRapidly available so administration may be timed to provide peak antioxidant protection\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eReproductive benefits for breeding stallions, and pregnant and lactating broodmares\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"layout layout-full-width  completely-full-width region-content us gb gc\"\u003e\n\u003cdiv class=\"full-width-container\"\u003e\n\u003cp\u003eThe chemical structures of synthetic and natural vitamin E differ. Natural vitamin E is recognized as d-alpha-tocopherol, and is made up of a single isomer. Synthetic vitamin E, termed dl-alpha tocopherol, contains a mixture of eight different isomers, four tocopherols and four tocotrienols. Of these eight, only one is molecularly equivalent to natural vitamin E. Sources of natural vitamin E, especially Nano-E, more effectively raise serum levels when compared to synthetic, as shown in Figure 1.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"layout layout-full-width  completely-full-width region-content us gb gc\"\u003e\n\u003cdiv class=\"full-width-container\"\u003e\n\u003cdiv class=\"alignleft\"\u003e\n\u003cp\u003e\u003cimg decoding=\"async\" class=\"aligncenter wp-image-26304 size-full\" src=\"https:\/\/ker.com\/wp-content\/uploads\/Nano-E-Charts_5000-IU-Dose-of-Vitamin-E_330x220.png\" alt=\"Graph showing change in serum vitamin E in horses given a 5000 IU does of Nano-E vs. synthetic vitamin E\" width=\"255\" height=\"170\"\u003e\u003c\/p\u003e\n\u003cp class=\"wp-caption-text\"\u003eFigure 1. Nano-E, a source of natural vitamin E, more effectively raises serum vitamin E levels when compared to synthetic vitamin E. Dose response equals multiple of 0 hr value which is represented as 1.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003eAlpha-tocopherol is the form of vitamin E that is most abundant in the body, and is therefore the most appropriate for use in supplementation.\u003c\/p\u003e\n\u003cp\u003eTo make alpha-tocopherol stable for use in most supplements, it must be chemically joined with an acid during manufacture, a process called esterification. The acid, in this case acetate, acts as a padlock or protective cap that shields alpha-tocopherol from the damages caused by exposure to oxidative forces. Without esterification, alpha-tocopherol can quickly denature, losing its antioxidant properties and rendering it ineffective.\u003c\/p\u003e\n\u003cp\u003eOnce ingested, esterified alpha-tocopherol is subjected to normal digestive enzymes. A certain group of enzymes called esterases are chemically capable of unlocking the padlock created through esterification. Once free, alpha-tocopherol is available for absorption with its antioxidant properties intact.\u003c\/p\u003e\n\u003cp\u003eFat-soluble vitamins like vitamin E must be offered to horses in a way that maximizes absorption. Because it is not mixed with other ingredients, the vitamin E in Nano-E does not need to be protected by esterification, but it must become water-soluble or dispersible in liquid. This presents a challenge: As everyone knows, oil and water don’t mix.\u003c\/p\u003e\n\u003cp\u003eResearchers developed a method by which fat-soluble vitamins can be absorbed with great efficiency. Because of its oily nature, vitamin E is hydrophobic (water-shunning). To overcome this, researchers use proprietary technology to encapsulate the vitamin E in nanoparticles and then surround each nanoparticle with a hydrophilic (water-loving) outer layer. The hydrophilic outer layer, as illustrated in Figure 2, allows the nanoparticles to be rapidly and evenly released in water-based environments such as the gastrointestinal tract. The differences in bioavailability among vitamin E sources are shown in Figure 3.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"layout half-and-half text-only  completely-full-width container-default no-padding\"\u003e\n\u003cdiv class=\"contain\"\u003e\n\u003cdiv class=\"cell half-and-half__left\"\u003e\n\u003cdiv class=\"content\"\u003e\n\u003cp\u003e\u003cimg decoding=\"async\" class=\"aligncenter wp-image-26308 size-full\" src=\"https:\/\/ker.com\/wp-content\/uploads\/Nano-E_Liposome-Encapsulation_330x220-3.png\" alt=\"Graphic showing the liposome encapsulation on Nano-E\" width=\"222\" height=\"148\"\u003e\u003c\/p\u003e\n\u003cp class=\"wp-caption-text\"\u003eFigure 2. Each water-soluble vitamin E nanoparticle in Nano-E is encapsulated or surrounded by liposomes, which allows the nanoparticle to mix evenly throughout a water-based environment such as the gastrointestinal tract.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"cell half-and-half__right\"\u003e\n\u003cdiv class=\"content\"\u003e\n\u003cp\u003e\u003cimg decoding=\"async\" class=\"aligncenter wp-image-33253\" src=\"https:\/\/ker.com\/wp-content\/uploads\/Relative-Bioavailability_Nano-E_UPDATED2.png\" alt=\"\" width=\"259\" height=\"200\" srcset=\"https:\/\/ker.com\/wp-content\/uploads\/Relative-Bioavailability_Nano-E_UPDATED2.png 569w, https:\/\/ker.com\/wp-content\/uploads\/Relative-Bioavailability_Nano-E_UPDATED2-300x231.png 300w\" sizes=\"(max-width: 428px) 100vw, 428px\"\u003e\u003c\/p\u003e\n\u003cp class=\"wp-caption-text\"\u003eFigure 3. Differences in relative bioavailability of various vitamin E sources. Nano-E is more bioavailable than other common sources of vitamin E. Synthetic bioavailability equals 1.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"layout layout-full-width  completely-full-width\"\u003e\n\u003cdiv class=\"full-width-container\"\u003e\n\u003cp\u003eThe greatest benefit of this unique delivery system is an increase in the bioavailability of vitamin E. The more vitamin E that is absorbed into the bloodstream, the more available it is for use as a body-wide antioxidant essential for tissue repair and for its imperative roles in various body systems.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"layout layout-full-width  completely-full-width checkbox-list-style add-space-to-layout region-content us\"\u003e\n\u003cdiv class=\"full-width-container\"\u003e\n\u003ch3\u003eNano-E is recommended for:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eRace and performance horses in intense wor\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eHorses recovering from illness or injur\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ePrior to or following stressful events such as weaning or trave\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eHorses with neurological or neuromuscular disease\u003c\/li\u003e\n\u003cli\u003eHorses in confinement or those not receiving fresh green grass\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eFeeding directions\u003c\/h3\u003e\n\u003cp\u003eDaily Use: give 4-8 mL (1000-2000 IU) per 1100 lb (500 kg) horse by mouth or top-dress on feed.\u003cbr\u003ePre-Competition: give 12-20 mL (3000-5000 IU) per 1100 lb (500 kg) horse 6-12 hours prior to competition or stressful event.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFeeding guidelines for racehorses:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eTrainers and managers should adhere to the regulations set forth by specific racing jurisdictions prior to using any feed additives or supplements.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/ker.com\/hisa-compliance\/\"\u003eHISA Compliance\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eGuaranteed Analysis\u003c\/h3\u003e\n\u003cp\u003e250 IU d-alpha-tocopherol per mL\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"KER","offers":[{"title":"Default Title","offer_id":54770267652468,"sku":"V20046-1","price":94.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0895\/4534\/3348\/files\/V20046-1.png?v=1781021204","url":"https:\/\/tackeria.com\/es\/products\/ker-nano-e-450ml","provider":"The Tackeria","version":"1.0","type":"link"}